Enzyme Blocking Therapy For Lymphomas

A new agent, depsipeptide is capable of blocking histone deacetylase (HDAC) and thereby stopping growth signals to malignant lymphoma cells. In recent NCI studies patients obtained objective responses. It is interesting to note that this agent also has activity in other tumors such as breast cancer and melanoma. Studies continue at the N.C.I. with this agent.

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February 15, 2002