High-Dose Chemotherapy Not Beneficial in Multiple Myeloma

Multiple Myeloma (MM) is a bone marrow disorder characterized by the uncontrolled growth of plasma cells. These cells elaborate proteins which can be detected at abnormal levels in the blood. Severe complications such as bone fractures and severe anemia are commonplace.

Traditional therapy consists of chemotherapy. Given at conventional doses remissions can be achieved in one half the cases. In an effort to improve upon these results high-dose chemotherapy has been attempted. Since the doses of drugs used deplete the bone marrow, stem cells need to be given so that bone marrow recovery can take place. Unfortunately, high-dose therapy did not result in improved survival. The trend away from high-dose chemotherapy has intensified over the past few years. Many other strategies are now in development for the treatment of Myeloma.

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February 05, 2002